Mannitol, USP grade, 1 lb. White crystalline D-mannitol for freeze-drying, microbiology media, formulation development, and boric acid titrations in labs.

Mannitol, USP Grade, 1 lb

$145.00

What it is. This mannitol is USP grade D-mannitol, a white crystalline sugar alcohol supplied in a 1 lb size. It is used as a laboratory reagent, a bulking agent in freeze-drying, a carbon source in microbiology media, and an excipient in formulation work.
What USP grade means. USP grade material meets the United States Pharmacopeia monograph for mannitol. The monograph sets a melting range of 164 to 169 °C, a specific rotation of +137 to +145 degrees under the USP method, a loss on drying of no more than 0.3%, and a test for reducing sugars.
Chemical identity. D-mannitol (CAS 69-65-8, C6H14O6, 182.17 g/mol) is a six-carbon sugar alcohol and an isomer of sorbitol. It has a density of about 1.49 g/cm³ and dissolves in water to about 156 g per liter at 18 °C.
Non-hygroscopic and stable. Unlike sorbitol, mannitol absorbs little moisture from the air. That stability is why it is widely used as a tablet diluent and as a bulking agent that gives freeze-dried products a firm, elegant cake.
Microbiology. Mannitol is the fermentable carbohydrate in mannitol salt agar, where organisms that ferment it, such as Staphylococcus aureus, produce acid that changes the medium's phenol red indicator to yellow.
Analytical chemistry. Mannitol is also used in the laboratory to complex boric acid, which turns the weak acid into a stronger acid that can be titrated sharply with sodium hydroxide.
Not for clinical use. This product is supplied for laboratory and manufacturing use. Mannitol injections used in medicine are separate, sterile products made under drug manufacturing controls.
Preparing solutions. Mannitol dissolves readily in warm water. For concentrated solutions, warm gently with stirring and allow the solution to cool, watching for crystallization at high concentrations, since mannitol solubility falls as temperature drops.
Handling at a glance. Mannitol has low toxicity and is not generally classified as hazardous. Avoid creating dust, wear safety glasses and gloves as standard practice, and keep the container closed in a dry place.

Technical Specifications

Chemical Name	D-Mannitol
CAS Number	69-65-8
EC Number	200-711-8
Synonyms	Mannitol, mannite, (2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol
Formula	C6H14O6
Molecular Weight	182.17 g/mol
Grade	USP
Melting Range (USP)	164 to 169 °C
Specific Rotation (USP method)	+137 to +145 degrees
Loss on Drying (USP)	0.3% max (105 °C, 4 hours)
Reducing Sugars	Meets USP test
Density	About 1.49 g/cm³
Water Solubility	About 156 g/L (18 °C)
Appearance	White crystalline powder
Hazard Profile	Not classified as hazardous (confirm on SDS)
Package Size	1 lb

Applications / Common Uses

Freeze-drying: Serves as a bulking agent for lyophilized formulations.
Microbiology media: Provides fermentable carbohydrate in mannitol salt agar.
Boric acid titration: Complexes boric acid for sharp titration.
Formulation work: Acts as a non-hygroscopic diluent.
Teaching labs: Demonstrates sugar alcohol chemistry.

Storage, Handling & Shipping

Store tightly closed in a cool, dry place at room temperature, away from strong oxidizers. Mannitol is stable and absorbs little moisture, but keeping it sealed preserves its USP quality.

Incompatible materials: Strong oxidizers.
Personal protection: Safety glasses, gloves, and dust control.
Spill response: Sweep up without raising dust and place in a closed container.
First aid: Eyes: rinse with water if irritation occurs.

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